It is not easy for us to write about cancer but we think that we should face what we fear and we should talk about something that eventually kills us so we can understand better. We have also covered other articles about cancer but in this article, we are going to write about the triple-negative breast cancer. The reason for that name is because it produces a small amount of protein HER2 as well as it doesn’t have receptors for hormones progesterone and estrogen. This leads to an inefficiency of medication which tends to aim at the above-mentioned factors. This is also the reason why this kind of cancer has been linked with high death rates.
“Asparagine bioavailability governs metastasis in a model of breast cancer.” is a study with Ph.D. Gregory Hannon as a leading author and is published in Nature medical journal and reviewed online at Cedars-Sinai Center for Bioinformatics and Functional Genomics. This study was backed by the National Cancer Institute of the National Institute of Health and organized in more than 10 different institutions.
The main aim of the research was to study the triple-negative cancer cells which are the fastest spreading and growing cells as well as the effect of asparagine in it. When experts from the research team provided laboratory mice with foods rich in asparagine, they saw that triple-negative cancer cells had the tendency to circulate more quickly. Foods which are rich in asparagine are dairy products, potatoes, eggs, fish, and others. Researchers also tried to lower the asparagine by providing mice with food like vegetable and fruits which have low levels of asparagine.
From the reduction of asparagine levels in mice with triple-negative breast cancer, researchers came to the conclusion that the capability of cancer to travel to other parts of the body decreased considerably. Researchers said that the presence of asparagine synthetase in an initial cancer is significantly correlated with a later cancer expansion.
The results of this research, backed by other previous similar studies, strongly suggest that the right changes in patient’s diet have the potential to influence the reaction from the treatment as well as it reduces the spread chances of this disease in the future. Furthermore, these studies, especially the studying of asparagine effects, may help in the development of other types of cancers, according to researchers.
Experts are planning to study healthy participants who will consume diets of low asparagine. If the results are satisfactory and the level of asparagine decreases for those participants then researchers plan to conduct other clinical trials with patients suffering from breast cancer. Except for diet restrictions, the latter clinical trial would also consist of performing chemotherapies as well as immunotherapy.