• Evidence in regenerating against depression
  • DHCA shortens the inflammatory substance interleukin 6 (IL-6).
  • Mal-gluc regulates the Rac1 gene.


Among the many feelings, sadness is one of the most common ones. One can feel sad when he/she is physically injured, when they lose a loved person, as a reaction to life difficulties and other causes. When these reasons happen for a long time as well as when they happen all at the same time, becoming thus devastating, someone suffers from depression. It is sad to know that statistically, 10 percent of those who suffer from depression commit suicide. Only half of those who suffer from depression are diagnosed and treated but they also experience different side effects. This is one of the main reasons why there are needed new therapies and strategy about depression.

Besides the above-mentioned feeling about depression, it is also worth mentioning that it affects the connection of neurons with each other, biological processes in lymph nodes as well as tissues which have the role of defending against illnesses.

Which is the research?

Antecedent studies have monitored that polyphenols derivative from grape can harmonize depression features but they haven’t quite understood nor explained how that harmonization process happens, until this study.

“Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice” is a study with leading author Ph.D. Jun Wang, published in the online journal Nature Communications on 2 February.

What did the study uncover?

From this research, experts monitored that a polyphenol composition derived from grape showed compelling evidence in regenerating against depression in lab mice. This bioactive composition is a mixture of concord grape juice, trans-resveratrol and grape seed extract. Dihydrocaffeic acid (DHCA) adjusts inflammation meanwhile malvidin-3′-O-glucoside (Mal-gluc) modulates synaptic plasticity, both causing an effect in depression resilience. DHCA helps in shortening an inflammatory substance called interleukin 6 (IL-6) which is excreted by macrophages as well as T cells in order to encourage immune response. This shortening is done by adjusting the gene of IL-6, more precisely by adjusting the non-coding sequence of it. On the other hand, Mal-gluc regulates the Rac1 gene by modulating histone acetylation. The treatment comprised of DHCA-Mal-gluc was also shown to be effective in debilitating phenotypes similar to depression.

This study demonstrates new clinical information about depression by addressing key methods of diseases throughout DNA epigenetic modification. It is important for this study to serve as a starting point in the development of new treatments which target pathological mechanisms, as mentioned above, like synaptic maladaptation as well as inflammation.